Researcher(s)
- Jacob Letnaunchyn, Chemistry, University of Delaware
Faculty Mentor(s)
- Don Watson, Department of Chemistry and Biochemistry, University of Delaware
Abstract
Bridged axially chiral biaryl scaffolds are a naturally occurring structure in nature. Axial chirality occurs around the aryl-aryl C-C bond due to a nonplanar arrangement of tetra ortho-substituted biaryl structures. These structures are also excellent at chirality transfer making them efficient ligands for catalysis. TunePhos ligands are a class of biaryl compounds which have a conformationally rigid yet tunable chiral axis. This rigidity results from a tether by which changing the length, can tune the dihedral angle of the biaryl axis. Utilizing previous advancements from our group in intermolecular asymmetric reductive cross-couplings and tethered aryl halides will allow for a streamlined and efficient synthesis of TunePhos type ligands.